PyGTD
Here’s one for the productivity pr0n crowd:
PyGTD is a simple system that incorporates major features from both Allen and Covey. It’s a small Python program that crunches any number of lightly-formatted text files containing project to-do lists, and creates a prioritized to-do list based on the next physical action in each project.
On a related note, I recently started using TaskFreak to manage my todo list at home. It’s a little limited, but it seems to be getting the job done and it was a snap to install.

I looked at PyGTD a while back and thought it was interesting but found it too complex for my taste. I ended up building a really weird homebrew GtD system using the filesystem and a bunch of unixy tools including python and cdargs. You can read more here.
Ever look at Devtodo? It’s another cool little CLI todo manager.